Initial Steps in Pyrimidine Synthesis in Ehrlich Ascites Carcinoma in Vitro
نویسندگان
چکیده
منابع مشابه
Effects of Ehrlich ascites antisera on the biochemical activities of Ehrlich ascites carcinoma cells in vitro.
Anl i-tumor sera are now being extensively used in investigations of the activities of neoplasms (e.g. 4-7, 9-13, 15). I t is already known (7), concerning their effects on the biochemical activities of tumors, that Ehrlich ascites carcinoma cells, treated with their antisera in the presence of comp]ement, lose their capacity to respire in the presence of glucose but not in the presence of succ...
متن کاملIn vitro culture of the Krebs ascites carcinoma and the Ehrlich ascites carcinoma of mice.
Several attempts in this laboratory in the last @ or 3 years to culture the Knebs-@ ascites carcinoma of mice had failed. The maximum survival time of the cells in culture was about 10 days. The media used always contained chicken embryo ex tract (CEE). Later, during efforts to develop a culture medium and technic by which single cell cultures could readily be initiated for single-cell irradiat...
متن کاملIncorporation by Ehrlich Ascites Cells in Vitro
I t was shown by Crabtree in 19~9 (8) that addition of glucose to tumor slices led to a decrease in their respiratory activity, and this fact has been confirmed (6, 10). The inhibitory effect of glucose on the respiratory activity of ascites cells is much greater and may approach 40 per cent (for reviews of the "Crabtree" or "reversed Pasteur" effect in ascites tumor cells, the recent papers by...
متن کامل4Aminopyrazolo (3,4d) pyrimidine: an Inhibitor of the Synthesis of Purines and Proteins in Ehrlich Ascites Cells
Carcinostatic activity of 4-(substituted amino)-pyrasolo(3,4-d pyrimidines was found to be confined to compounds whose basic dissociation constants approximated that of adenine (1, 2). In addition, the toxicity of 4-aminopyrazolo(3,4d)pyrimidine could be reversed by adcnine or adenine-containing compounds in a number of biological systems (1, 3-7). These findings led to the hypothesis that the ...
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خلاصه : کارسینوم تهاجمی سینه پستان علت مرگ و میر حاصل از سرطان خانم ها در بسیاری از کشورها می باشد. این کارسینوم بدنبال کارسینوم در محل ایجاد می شود. در کارسینوم در محل سلول های توموری هنوز نتوانسته اند که از غشاء پایه عبور کنند. در عبور از مرحله کارسینوم در محل به مرحله تهاجمی، سلولهای سرطانی تغییرات مولکولی بسیاری پیدا میکنند که هنوز علت عده ای از آنها مشخص نشده است. در این مطالعه ما بررسی کر...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1967
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)99352-x